1.
Southeast Asian J Trop Med Public Health
;
1995 ; 26 Suppl 1(): 92-5
Article
in English
| IMSEAR
| ID: sea-31797
ABSTRACT
The chromosome in situ suppression hybridization or chromosome painting technic was applied to confirm and eliminate the markers involving chromosome 21 segments using a chromosome 21 DNA library. The library ATCCLL21SNO2 was amplified, directly biotinylated using the polymerase chain reaction. The results demonstrated a translocation of chromosome 21 material on chromosome 2 and X and eliminate the origin of the marker. Thus, the technique provides an important tool to complement the conventional G-banding technic.